You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. In addition, certain drugs used to treat cancer, known as cytotoxic chemotherapy drugs, can result in anisocytosis.Īnisocytosis may also be seen in those with cardiovascular disease and some cancers. Other disorders that can cause anisocytosis include: Pernicious anemia is an autoimmune disorder. Pernicious anemia: This is a type of macrocytic anemia caused by the body not being able to absorb vitamin B-12.It’s typically caused by a deficiency in folate or vitamin B-12. Megaloblastic anemia: When there are fewer than normal RBCs and the RBCs are larger than normal (macrocytic anisocytosis), this anemia results.
Autoimmune hemolytic anemias: This group of disorders occur when the immune system mistakenly destroys RBCs.It usually results in microcytic anisocytosis. Thalassemia: This is an inherited blood disorder in which the body makes abnormal hemoglobin.Sickle cell anemia: This genetic disease results in RBCs with an abnormal crescent shape.
It occurs when the body doesn’t have enough iron, either due to blood loss or a dietary deficiency. Iron deficiency anemia: This is the most common form of anemia.There are several different types of anemia that can lead to unequally sized RBCs, including: There might be too few RBCs, the cells might be irregular in shape, or they may not have enough of an important compound known as hemoglobin.
In anemia, the RBCs are unable to carry enough oxygen to your body’s tissues.
Anisocytosis is most commonly a result of another condition called anemia.
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